ABSTRACT
Aim. To assess the association of hypertension with the severe forms and fatal outcomes of Coronavirus disease 2019 (COVID-19). Material and Methods. This retrospective cohort study involved adult patients (>= 18 years old), admitted to the University hospital No 4 of Sechenov University (Moscow, Russia) between 08 April 2020 and 19 November 2020 with clinically diagnosed or laboratory -confirmed COVID-19. The cohort included 1637 patients. The primary outcome was all-cause in-hospital mortality. The secondary out-comes included intensive care unit admission (ICU) and invasive ventilation. Multiple logistic regression was performed to assess the in-dependent association between risk factors and endpoints. Results. A total of 1637 patients were included in the study. 51.80% (n=848) of the subjects were males. The median age was 59.0 (48.0;70.0) years and 55.90% (n=915) had pre-existing diagnosis of hypertension. Patients with hypertension had significantly more severe lung injury based on chest CT scan findings as well as lower oxygen saturation (SpO(2)). More of them were admitted to ICU and placed on invasive ventilation. The hypertension group also had higher mortality. Age, hypertension, glucose, C-reactive protein and decreased platelet count were independently associated with mortality, hypertension having the strongest association (OR 1.827, 95% CI 1.174-2.846, p=0.008). Age, hypertension, neutrophil count, platelet count, glucose, and CRP were independently associated with ICU admission, with hypertension having the strongest association (OR 1.595, 95% CI 1.178-2.158, p=0.002). Age, hypertension, glucose, CRP and decreased platelet count were independently associated with invasive ventilation, with hypertension having the strongest association (OR 1.703, 95% CI 1.151-2.519, p=0.008).Based on the multiple logistic regression models, odds of death, ICU admission, and invasive ventilation were higher in the hypertension group as compared to the group without hyperten-sion. Conclusion. Hypertension can be an independent predictor of severe COVID-19 and adverse outcomes, namely death, ICU admission, and invasive ventilation in hospitalized patients.
ABSTRACT
Aim. To assess the association of hypertension with the severe forms and fatal outcomes of Coronavirus disease 2019 (COVID-19). Material and Methods. This retrospective cohort study involved adult patients (>=18 years old), admitted to the University hospital 4 of Sechenov University (Moscow, Russia) between 08 April 2020 and 19 November 2020 with clinically diagnosed or laboratory-confirmed COVID-19. The cohort included 1637 patients. The primary outcome was all-cause in-hospital mortality. The secondary outcomes included intensive care unit admission (ICU) and invasive ventilation. Multiple logistic regression was performed to assess the independent association between risk factors and endpoints. Results. A total of 1637 patients were included in the study. 51.80% (n=848) of the subjects were males. The median age was 59.0 (48.0;70.0) years and 55.90% (n=915) had pre-existing diagnosis of hypertension. Patients with hypertension had significantly more severe lung injury based on chest CT scan findings as well as lower oxygen saturation (SpO2). More of them were admitted to ICU and placed on invasive ventilation. The hypertension group also had higher mortality. Age, hypertension, glucose, C-reactive protein and decreased platelet count were independently associated with mortality, hypertension having the strongest association (OR 1.827, 95% CI 1.174-2.846, p=0.008). Age, hypertension, neutrophil count, platelet count, glucose, and CRP were independently associated with ICU admission, with hypertension having the strongest association (OR 1.595, 95% CI 1.178-2.158, p=0.002). Age, hypertension, glucose, CRP and decreased platelet count were independently associated with invasive ventilation, with hypertension having the strongest association (OR 1.703, 95% CI 1.151-2.519, p=0.008).Based on the multiple logistic regression models, odds of death, ICU admission, and invasive ventilation were higher in the hypertension group as compared to the group without hypertension. Conclusion. Hypertension can be an independent predictor of severe COVID-19 and adverse outcomes, namely death, ICU admission, and invasive ventilation in hospitalized patients.Copyright © 2023 Stolichnaya Izdatelskaya Kompaniya. All rights reserved.
ABSTRACT
Aim. To assess the association of hypertension with the severe forms and fatal outcomes of Coronavirus disease 2019 (COVID-19). Material and Methods. This retrospective cohort study involved adult patients (>=18 years old), admitted to the University hospital 4 of Sechenov University (Moscow, Russia) between 08 April 2020 and 19 November 2020 with clinically diagnosed or laboratory-confirmed COVID-19. The cohort included 1637 patients. The primary outcome was all-cause in-hospital mortality. The secondary outcomes included intensive care unit admission (ICU) and invasive ventilation. Multiple logistic regression was performed to assess the independent association between risk factors and endpoints. Results. A total of 1637 patients were included in the study. 51.80% (n=848) of the subjects were males. The median age was 59.0 (48.0;70.0) years and 55.90% (n=915) had pre-existing diagnosis of hypertension. Patients with hypertension had significantly more severe lung injury based on chest CT scan findings as well as lower oxygen saturation (SpO2). More of them were admitted to ICU and placed on invasive ventilation. The hypertension group also had higher mortality. Age, hypertension, glucose, C-reactive protein and decreased platelet count were independently associated with mortality, hypertension having the strongest association (OR 1.827, 95% CI 1.174-2.846, p=0.008). Age, hypertension, neutrophil count, platelet count, glucose, and CRP were independently associated with ICU admission, with hypertension having the strongest association (OR 1.595, 95% CI 1.178-2.158, p=0.002). Age, hypertension, glucose, CRP and decreased platelet count were independently associated with invasive ventilation, with hypertension having the strongest association (OR 1.703, 95% CI 1.151-2.519, p=0.008).Based on the multiple logistic regression models, odds of death, ICU admission, and invasive ventilation were higher in the hypertension group as compared to the group without hypertension. Conclusion. Hypertension can be an independent predictor of severe COVID-19 and adverse outcomes, namely death, ICU admission, and invasive ventilation in hospitalized patients.Copyright © 2023 Stolichnaya Izdatelskaya Kompaniya. All rights reserved.
ABSTRACT
INTRODUCTION. Over the past few months, the topic of multisystem inflammatory syndrome in children has been evolving at an extraordinary pace, as evidenced by the increasing number of publications on this subject. The disease does not begin to develop immediately, not at the moment the virus enters the body, but after some time, and that is 14-21 days later. This is evidenced by the presence of IgG antibodies and the absence of RNA virus in the biological loci. Representatives of the Pediatric Intensive Care Society of Great Britain felt it necessary to circulate the "PICS Statement”, which contained data on the increasing number of children with a new multisystem inflammatory disease associated with positive tests for SARS-CoV-2. However, it should be noted that this association was confirmed in only some patients by appropriate tests performed in laboratory settings. The course of the disease was similar to a toxic shock syndrome and atypical Kawasaki disease, for which the characteristic symptoms are heart disease, abdominal pain and gastrointestinal symptoms. The patients showed abnormalities in blood parameters, changes in the number of blood corpuscules, the level of C-reactive protein (CRP), ferritin, troponin, brain natriuretic propeptide (NT-proBNP) was high. AIM. Using a case study to show the importance of a timely detection, treatment and follow-up of children with a new coronavirus infection. MATERIAL AND METHODS. The mother of a 3-month-old child (the subject of the study) applied to the follow-up office of the Republican Children's Clinical Hospital in Ufa with a history of COVID-19 infection. The following were used to diagnose the current condition: copying of data from medical records, clinical examination with assessment of physical and psychomotor development, consultations of single-skilled specialists to make a diagnosis, laboratory and instrumental examinations. RESULTS AND DISCUSSION. The article presents an observation of a 1-year-old patient with COVID-19 infection complicated by multisystem inflammatory syndrome, including the Kawasaki syndrome. In this patient, against the background of the third hospitalization for COVID-19, a positive dynamics of the course of the disease was achieved with discharge to the outpatient stage of treatment and follow-up. CONCLUSION. Lesions of organs and organ systems caused by COVID-19 require an integrated approach to diagnosis and management of patients. Further accumulation of data on diagnosis and clinical course of the new coronavirus infection in children remains an urgent scientific and practical task. © 2022, Nailya R. Hafizova, Dinara R. Merzlyakova, Natalia A. Druzhinina, Galina P. Shiryaeva, Tatiana B. Khayretdinova, Liliya R. Imaeva, Gulnaz A. Vakhitova, Aliya R. Khabibullina, Alfiya I. Nazarova This is an open article under the CC BY license.